Plasma Cystatin C and Estimates of Glomerular Filtration Rate Using Cystatin C Independently Diagnose Acute Kidney Injury in Critically Ill Patients with Sepsis
| Autor: | Iqbalmunawwir Ab Rashid, Azrina Ralib, Nur Fariza Ramly, Mohd Basri Mat Nor, Nur Aisyah Ishak, Suhaila Nanyan |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology business.industry Acute kidney injury Urology Renal function General Medicine urologic and male genital diseases medicine.disease Interim analysis female genital diseases and pregnancy complications Procalcitonin Sepsis Cystatin C Cohort biology.protein Medicine SOFA score business |
| Zdroj: | IIUM Medical Journal Malaysia. 16 |
| ISSN: | 2735-2285 1823-4631 |
| DOI: | 10.31436/imjm.v16i1.1166 |
| Popis: | Introduction: Plasma Cystatin C (CysC) is as an early functional marker for acute kidney injury. Estimates of glomerular filtration rate using CysC (eGFRCysC) has been used in some clinical setting. We evaluated the utility of CysC and eGFRCysC in diagnosing acute kidney injury (AKI) and predicting death in critically ill patients with sepsis. Materials and method: This is an interim analysis of single centre, prospective observational study of critically ill patients. Inclusion criteria were patients older than 18 years old with sepsis and procalcitonin > 0.5ng/ml. Plasma creatinine and CysC were measured on admission, and eGFRCysC. AKI was defined based on the plasma creatinine criteria of the KDIGO guideline. Results: Thirty one patients were recruited so far, of which 13 (41.9%) had AKI and six died. CysC were higher in patients with AKI versus No AKI (p |
| Databáze: | OpenAIRE |
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