Use of Π-Acceptors for Spectrophotometric Determination of Dicyclomine Hydrochloride
| Autor: | Kamal M Abdel Moneim, Lories I. Bebawy, Yosry M Issa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Dicycloverine Chromatography medicine.diagnostic_test Chloranil Dicyclomine Ampoule Colorimetry (chemical method) Analytical Chemistry chemistry.chemical_compound chemistry Spectrophotometry medicine Environmental Chemistry Agronomy and Crop Science Quantitative analysis (chemistry) Dicyclomine Hydrochloride Food Science medicine.drug |
| Zdroj: | Journal of AOAC INTERNATIONAL. 86:1-7 |
| ISSN: | 1944-7922 1060-3271 |
| DOI: | 10.1093/jaoac/86.1.1 |
| Popis: | Simple, rapid, accurate, and sensitive spectrophotometric methods are described for the determination of dicyclomine hydrochloride. The methods are based on the reaction of this drug as an n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoqunione (DDQ), p-chloranilic acid (p-CA), and chloranil (CL) as Π-acceptors to give highly colored complex species. The colored products are measured spectrophotometrically at 456, 530, and 650 nm for DDQ, p-CA, and CL, respectively. Optimization of the different experimental conditions were studied. Beer's law was obeyed in concentration ranges of 20–100, 50–250, and 80–600 μg/mL for DDQ, p-CA, and CL, respectively. Colored complexes are produced in organic solvents and are stable for at least 1 h. The methods were applied to Spasmorest™ antispasmotic tablets and ampoules with good accuracy and precision. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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