Intoxication aigüe au vérapamil : attention à l’effet retard

Autor:	P. Maragnes, C. Charpentier, M. Jokic, F. Villedieu, Fabien Labombarda, M. Flandrois
Rok vydání:	2014
Předmět:	Bromazepam medicine.medical_specialty medicine.drug_class business.industry Calcium channel Gastric motility Poison control Calcium channel blocker Surgery Epinephrine Anesthesia Intensive care Pediatrics Perinatology and Child Health medicine Verapamil business medicine.drug
Zdroj:	Archives de Pédiatrie. 21:1344-1347
ISSN:	0929-693X
Popis:	Intoxication with calcium channel inhibitory drugs is rare but mortality rates reach 10 %. We report the case of a 5-year-old girl who had ingested five 240-mg tablets of extended-release verapamil (VLP) and a tablet of bromazepam. Thirty hours after the ingestion she had a vasoplegic shock, heart conduction disorders, and metabolic complications. She was treated in pediatric intensive care with continuous epinephrine and insulin and recovered completely 60h after the ingestion. This case underlines the danger of calcium channel blocker overdose, increased by the extended-release mechanism: the drug effect is to slow down gastric motility - which explains the latency of the symptoms - but this also increases the drug absorption, inducing a vicious circle. These mechanisms in calcium blocker intoxication need to be kept in mind in order to decrease the mortality of such accidents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b043abcb16e2af209a17248de9fb505 https://doi.org/10.1016/j.arcped.2014.09.013 Zobrazit plný text záznamu Full Text from ScienceDirect