Candidate gene association study of UCP3 variant rs1800849 with T2D in Mizo population of Northeast India
| Autor: | Vinod Singh, Ekta Rai, Swarkar Sharma, Shruti Sharma, John Zohmingthanga, Nachimuthu Senthil Kumar, Freda Lalrohlui, Indu Sharma, Tasmeen Javed Parihar, Sarmeela Sharma, Varun Sharma |
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| Rok vydání: | 2020 |
| Předmět: |
Genetics
education.field_of_study Candidate gene endocrine system diseases Genetic heterogeneity business.industry Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Internal Medicine Genetic predisposition TaqMan Medicine 030212 general & internal medicine Allele education business Gene UCP3 |
| Zdroj: | International Journal of Diabetes in Developing Countries. 40:513-517 |
| ISSN: | 1998-3832 0973-3930 |
| DOI: | 10.1007/s13410-020-00812-9 |
| Popis: | Uncoupling protein 3 (UCP3) has been identified as a type 2 diabetes (T2D) candidate gene and variant rs1800849 is of potential interest as it is present in the regulatory region of UCP3. The aim of the present candidate gene case-control association study was to evaluate the association of variant rs1800849 of UCP3 with T2D in Mizo population from Northeast India. The variation was genotyped using TaqMan allele discrimination assay in 767 individuals (425 cases and 342 healthy controls). The variant rs1800849 of UCP3 was not found to be significantly associated with T2D (p-value = 0.733) in studied population group. Thus, it is concluded that the present study could not replicate the association of variant rs1800849 with genetic susceptibility to T2D in the Mizo population group. This absence of association highlights the genetic heterogeneity prevalent in Indian population groups and warrants screening of other T2D candidate genes in Mizo population group. |
| Databáze: | OpenAIRE |
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