Potential Role of Serum S-100β Protein as a Predictor of Cardiotoxicity and Clinical Poor Outcome in Acute Amphetamine Intoxication
| Autor: | Asmaa Fady Sharif, Abdullah Z. Al-Asmari, Dina El Gameel, Eman Elsheikh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cardiotoxicity business.industry Neurotoxicity 030204 cardiovascular system & hematology Toxicology medicine.disease S 100β protein Poison control center QT interval 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Toxicity medicine Cardiology and Cardiovascular Medicine Amphetamine Prospective cohort study business Molecular Biology medicine.drug |
| Zdroj: | Cardiovascular Toxicology. 21:375-386 |
| ISSN: | 1559-0259 1530-7905 |
| DOI: | 10.1007/s12012-020-09630-1 |
| Popis: | Cardio- and neurotoxicity of amphetamines play an important role in worsening morbidity, making the initial evaluation of the patient’s status a potentially lifesaving action. The current study hypothesized that the S-100β serum level could predict the severity of acute amphetamine toxicity and the in-hospital outcome. The current study is a prospective cohort study conducted on 77 patients diagnosed with acute amphetamine exposure and referred to Aseer Poison Control Center, Saudi Arabia. The patients admitted to ICU showed significantly higher serum levels of S-100β in comparison to those not admitted (p 0.430 ug/L, the sensitivity of S-100β serum level as severity predictor was 100%, and the specificity was 74.1%. In conclusion, the current study revealed that the S-100β serum level could be used as an outcome predictor in hospital admission cases due to toxic amphetamine exposure and offers an idea about the cardiac and neuronal involvement. This can help select patients who will benefit most from ICU admission and early management and assess the severity of cases in settings where GC–MS is not available. |
| Databáze: | OpenAIRE |
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