Abstract P158: Excess CVD Risk Factors, CAC and Carotid IMT in US South Asians: Preliminary Results from the MASALA study

Autor: Alka M Kanaya, Michael Schembri, Swapna Dave, Ritu Gupta, Neerja Khurana, Shweta Srivastava, Matthew J Budoff, David Herrington, Kiang Liu, Namratha Kandula
Rok vydání: 2012
Předmět:
Zdroj: Circulation. 125
ISSN: 1524-4539
0009-7322
2010-2011
DOI: 10.1161/circ.125.suppl_10.ap158
Popis: Background: South Asians (SA) have a disproportionate risk of heart disease and diabetes and are at greater risk for death from heart disease compared to other racial/ethnic groups. There are almost 3 million SA in the United States; SA are currently the second fastest growing U.S. ethnic group after Latinos. Objectives: To assess the prevalence of cardiovascular (CVD) risk factors and subclinical atherosclerosis in SA using similar methods and measures from the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study is a community-based cohort enrolling 900 SA between 40-79 years without known CVD at two clinical centers (University of California, San Francisco and Northwestern University, Chicago). At baseline, we are collecting demographic, cultural and lifestyle information, fasting blood tests, 2-hour glucose tolerance test, physical examination, carotid ultrasound for intima media thickness (IMT) and CT for coronary artery calcium (CAC). Results: To date, we have enrolled 368 participants in MASALA with a mean age of 56±9 years, of whom 98% are immigrants who have lived in the U.S. an average of 27±11 years. A majority are immigrants from India (85%), 6% from Pakistan, 1% each from Bangladesh, Sri Lanka and Nepal, and 6% from other diaspora countries. The table shows demographic, behavioral, and clinical characteristics of the cohort. The cohort has higher socioeconomic status, lower smoking and alcohol use, very low exercise, modest BMI, and higher prevalence of hypertension, diabetes, and subclinical atherosclerosis than reported in MESA ethnic groups. Conclusion: Despite having high socioeconomic attainment and modest BMI, SA have low physical activity levels and high prevalence of CVD risk factors and atherosclerosis. This population-based study of U.S. South Asians will provide further insights into the clinical, behavioral, and socio-cultural factors contributing to heart disease. MASALA participant characteristics, 2010-2011 Overall n=368 Men n=271 Women n=97 Education ≥Bachelor's degree, % 86 87 83 Family income ≥$100,000, % 60 62 55 Current smoking, % 5 6 1 Alcohol intake, >1 drink/week 39 45 22 Exercise, median MET-min/week 960 982 885 BMI, kg/m2 26.6±4.9 26.5±4.9 26.8±5.0 Waist circumference, cm 95±10 97±10 91±11 LDL, mg/dl 108±32 108±31 109±32 HDL, mg/dl (median) 47 44 57 Triglycerides, mg/dl (median) 122 127 112 Hypertension, % 46 48 41 Diabetes, % 26 28 20 Common carotid IMT, mm 0.91±0.22 0.92±0.22 0.89±0.24 Internal carotid IMT, mm 1.24±0.44 1.24±0.45 1.22±0.42 CAC score, zero 1-100 >100 50 31 19 44 35 21 69 20 11
Databáze: OpenAIRE
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