Instrumental learning within the spinal cord: VI

Autor:	Kamran Janjua, Robin L. Joynes, James W. Grau
Rok vydání:	2004
Předmět:	business.industry Central nervous system Glutamate receptor Antagonist Hindlimb Spinal cord Behavioral Neuroscience medicine.anatomical_structure NMDA receptor Medicine Analysis of variance business 2-Amino-5-phosphonovalerate Neuroscience
Zdroj:	Behavioural Brain Research. 154:431-438
ISSN:	0166-4328
DOI:	10.1016/j.bbr.2004.03.030
Popis:	Prior studies have shown that circuits within the spinal cord can support a simple form of instrumental learning. Spinally transected rats are given shock to one hind leg whenever the leg is extended. This response-outcome contingency causes an increase in flexion duration. The present experiments examine whether the NMDA receptor is involved in the acquisition and maintenance of this instrumental response. Experiment 1 showed that the NMDA receptor antagonist 2-amino-5-phosphonovalerate acid (AP5) reduces instrumental responding in a dose-dependent fashion. Experiment 2 showed that AP5 given after training eliminates the increase in flexion duration. The results implicate the NMDA receptor in the acquisition and maintenance of spinally mediated instrumental behavior.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0adb01e1925ba72128963db538495f9e https://doi.org/10.1016/j.bbr.2004.03.030 Zobrazit plný text záznamu Full Text from ScienceDirect