Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time C Breath Test (BreathID System)

Autor:	Yusuke Sekino, Hiroshi Iida, Ayumu Goto, Takashi Nonaka, Eiji Sakai, Kunihiro Hosono, Tamon Ikeda, Takuma Higurashi, Tomoko Koide, Yasunari Sakamoto, Koji Fujita, Eiji Gotoh, Hidenori Ohkubo, Hirokazu Takahashi, Masato Yoneda, Hiroki Endo, Shin Maeda, Atsushi Nakajima, Masahiko Inamori, Yasunobu Abe, Eiji Yamada
Rok vydání:	2011
Předmět:	Breath test medicine.medical_specialty Gastric emptying medicine.diagnostic_test business.industry digestive oral and skin physiology Gastroenterology Reflux Crossover study Mosapride Internal medicine Medicine Neurology (clinical) business Research software Liquid meal medicine.drug
Zdroj:	Journal of Neurogastroenterology and Motility. 17:395-401
ISSN:	2093-0887 2093-0879
Popis:	BACKGROUND/AIMS The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals. METHODS Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A (13)C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (β version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test. RESULTS Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone. CONCLUSIONS This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ada12a840eef6b093e3a7d8b543c818 https://doi.org/10.5056/jnm.2011.17.4.395 Zobrazit plný text záznamu