METHEMOGLOBINEMIE CONSECUTIVE A L’ABUS DE GEL DE LIDOCAÏNE VISQUEUSE
| Autor: | Jean-Pierre Goullé, M. Borel, C. Lacroix, M. Peureux |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Drug
Chemotherapy Lidocaine Local anesthetic medicine.drug_class business.industry medicine.medical_treatment media_common.quotation_subject General Medicine Antiarrhythmic agent Methemoglobinemia medicine.disease Anticonvulsant hemic and lymphatic diseases Anesthesia Toxicity medicine business medicine.drug media_common |
| Zdroj: | Acta Clinica Belgica. 57:58-62 |
| ISSN: | 2295-3337 1784-3286 |
| DOI: | 10.1179/acb.2002.080 |
| Popis: | Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1 % following repeated Xylocaine® gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect. |
| Databáze: | OpenAIRE |
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