Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice
| Autor: | Nyamai Dw, Mathew Piero Ngugi, Alex K. Machocho, Njogu Sm, Arika Wm, Ngeranwa Jjn, Njagi Enm |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Ethyl acetate 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Diabetes mellitus Internal medicine Alloxan medicine Aqueous solution biology Traditional medicine Maytenus business.industry food and beverages Diabetic mouse Metabolism medicine.disease biology.organism_classification 030104 developmental biology Endocrinology chemistry business |
| Zdroj: | Journal of Diabetes & Metabolism. 7 |
| ISSN: | 2155-6156 |
| DOI: | 10.4172/2155-6156.1000685 |
| Popis: | Maytenus putterkloides has been used traditionally to manage several diseases including diabetes, however, its efficacy has not been scientifically evaluated. The aim of this study was to determine the in vivo hypoglycemic activity of aqueous and ethyl acetate leaf extract of this plant in male swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice through oral and intraperitoneal routes. Phytochemical composition was assessed using standard procedures. The aqueous and ethyl acetate leaf extract of this plant showed hypoglycemic activity at dose levels of 50, 100, 200, 300 mg/kg body weight in a dose independent manner via both routes. The extracts contained total phenolics, saponins, tannins, flavonoids, alkaloids and phytonutrients; vitamins B1, B3, and C. The observed hypoglycemic activity could be associated with the phytochemicals present in this plant extract. |
| Databáze: | OpenAIRE |
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