Antibody-Induced Alterations of Thyroid Hormone Receptor during Experimental Thyroglobulin Immunization in Rabbits
| Autor: | Subhra Lahiri, Alokananda Chakraborty, Arun K. Ray |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
endocrine system
medicine.medical_specialty Nutrition and Dietetics Triiodothyronine Thyroid hormone receptor endocrine system diseases biology medicine.medical_treatment Clinical Biochemistry Medicine (miscellaneous) Dissociation constant Endocrinology Thyroid peroxidase Internal medicine biology.protein medicine Thyroglobulin Antibody Thyroid hormone binding Receptor |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition. 18:73-77 |
| ISSN: | 1880-5086 0912-0009 |
| DOI: | 10.3164/jcbn.18.73 |
| Popis: | Maximum binding capacity and dissociation constant of the triiodothyronine receptor were studied in isolated hepatic nuclei of thyroglobulin-immunized rabbits on the 98th day after the first injection. Study revealed a significant (p < 0.001) increase in maximum binding capacity and in dissociation constant and significantly lower (p < 0.001) levels of serum triiodothyronine and thyroxine. These results reflect an alteration in thyroid hormone binding capacity during experimental thyroglobulin immunization |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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