tert-Butyl hydroperoxide, an organic peroxide, causes temporary delay in hair growth in a neonatal rat model
| Autor: | George W. Elgart, Tongyu C. Wikramanayake, Jessica Simon, Joaquin J. Jimenez, Lucia M. Mauro, Carmen Perez, Lawrence A. Schachner, B. Roberts, Elizabeth Alvarez‐Connelly |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Organic peroxide integumentary system Chemistry Morphogenesis Dermatology Vitiligo medicine.disease Hair follicle medicine.disease_cause chemistry.chemical_compound medicine.anatomical_structure Endocrinology Biochemistry Apoptosis Internal medicine medicine tert-Butyl hydroperoxide Ultraviolet light Oxidative stress |
| Zdroj: | Clinical and Experimental Dermatology. 36:661-664 |
| ISSN: | 0307-6938 |
| DOI: | 10.1111/j.1365-2230.2011.04016.x |
| Popis: | The skin is constantly exposed to relatively high levels of ultraviolet light and high oxygen tension, and to oxidizing chemicals present in cosmetic and pharmaceutical products. Exposure to these environmental challenges, in addition to oxidants produced during normal cellular processes, can result in oxidative stress that causes tissue and cellular damage.1–3 In the skin, oxidative stress has been associated with the development of vitiligo and rosacea.4,5 In addition, susceptibility of melanocytes to oxidative stress may be responsible for senile hair greying.6–8 It is important to understand the effects of oxidants on skin keratinocytes because these cells encounter the highest levels of environmental oxidants. Previous studies have shown that cultured keratinocytes suffer irreversible damages with long-term, high-dose treatment of tert-butyl hydroperoxide (tBHP), an organic peroxide, although the damage was reversible in keratinocytes given short-term, low-dose treatment.9 In addition, topical application of linolein hydroperoxides (lipid peroxides) in adult mice was shown to induce apoptosis of hair follicle (HF) keratinocytes and subsequent early onset of catagen (HF regression phase).10 However, it is not known whether such oxidant-induced HF damage is permanent. In this study, we investigated the effects of tBHP on HF growth in neonatal Sprague–Dawley (SD) and Long–Evans (LE) rat pups. We treated the pups daily for 6 days and monitored hair growth for an additional 2 weeks. Use of neonatal rats facilitated the analysis of oxidative damage on visible hair-shaft growth during the synchronized postnatal HF morphogenesis. Additionally, use of the pigmented LE rats also allowed us to examine the effects of tBHP on hair-shaft pigmentation. |
| Databáze: | OpenAIRE |
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