ChemInform Abstract: Synthesis of 5-Phosphate-D-arabinohydroxamic Acid, a Potent Transition State Analogue Inhibitor of 6-Phosphate-D-glucose Isomerases

Autor:	Alain Gaudemer, Laurent Salmon, Corinne Bonnette
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Transition state analog D-Glucose Stereochemistry General Medicine Isomerase Phosphate Derivative (chemistry)
Zdroj:	ChemInform. 27
ISSN:	0931-7597
Popis:	The first hydroxamate-based and potent transition state analogue (TSA) inhibitor of 6-phosphate-D-glucose isomerases, 5-phosphate-D-arabinohydroxamic acid 3 , has been synthesized by conversion of D-arabinose to a protected derivative of 5-phosphate-D-arabinonic acid and introduction of the hydroxamate group by coupling with O-benzylhydroxylamine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ac14fea213b478a9379b0e919317ef8 https://doi.org/10.1002/chin.199626243 Zobrazit plný text záznamu Plný text