ChemInform Abstract: Synthesis of 5-Phosphate-D-arabinohydroxamic Acid, a Potent Transition State Analogue Inhibitor of 6-Phosphate-D-glucose Isomerases
Autor: | Alain Gaudemer, Laurent Salmon, Corinne Bonnette |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 27 |
ISSN: | 0931-7597 |
Popis: | The first hydroxamate-based and potent transition state analogue (TSA) inhibitor of 6-phosphate-D-glucose isomerases, 5-phosphate-D-arabinohydroxamic acid 3 , has been synthesized by conversion of D-arabinose to a protected derivative of 5-phosphate-D-arabinonic acid and introduction of the hydroxamate group by coupling with O-benzylhydroxylamine. |
Databáze: | OpenAIRE |
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