Antiepileptic Drugs in Mood-Disordered Patients
| Autor: | David J. Muzina, Benedikt L. Amann, Omar Elhaj, Prashant Gajwani, Keming Gao, Joseph R. Calabrese, Heinz Grunze, A. Forsthoff |
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| Rok vydání: | 2005 |
| Předmět: |
Topiramate
Pediatrics medicine.medical_specialty medicine.drug_class business.industry medicine.medical_treatment Mood stabilizer Carbamazepine Lamotrigine Pharmacology medicine.disease Vigabatrin Anticonvulsant Neurology mental disorders medicine Neurology (clinical) Bipolar disorder medicine.symptom business Mania medicine.drug |
| Zdroj: | Epilepsia. 46:38-44 |
| ISSN: | 0013-9580 |
| Popis: | Bipolar disorder is a common, recurrent, often severe mental disorder that, without adequate treatment, is associated with high rates of morbidity and mortality. We review the evidence on the efficacy of a spectrum of antiepileptic drugs (AED) in bipolar disorder. Most studies have been carried out with carbamazepine (CBZ), valproate (VPA), and lamotrigine (LTG). All three of these AEDs have been shown to be of value in the management of patients with bipolar illnesses. VPA and CBZ seem to exert stronger antimanic effects and, to a lesser degree, acute antidepressant efficacy. LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders. |
| Databáze: | OpenAIRE |
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