Downstream Process Design, Scale-Up Principles, and Process Modeling
| Autor: | John Joseph, Karol M. Łącki, Kjell O. Eriksson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
Process modeling Manufacturing process Computer science media_common.quotation_subject ComputerApplications_COMPUTERSINOTHERSYSTEMS Process design 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Sizing Strategy development Interdependence Product lifecycle 010608 biotechnology SCALE-UP Systems engineering 0210 nano-technology media_common |
| Popis: | The chapter provides the reader with the basic understanding of process design and discusses few concepts important for consideration during this stage of the product lifecycle. The main focus of the chapter is on the downstream purification part of a manufacturing process. However, because the successful design of a downstream process always takes into account the various interdependencies between upstream and downstream parts, some important aspects of the upstream process design are also discussed. Throughout the chapter, an example of a universal roadmap for process and control strategy development is outlined and discussed by focusing on general rules and dedicated tools for developing, characterizing, and scaling-up of downstream processes. Generally applicable methodologies for sizing of filtration and chromatography unit operations are also outlined. Because the process design should also account for the functionality and limitations of commercial manufacturing equipment, examples of relevant constraints are given. The final section of this chapter discusses the use of various computational modeling strategies that could facilitate the design and scale-up of manufacturing processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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