A7.23 The HLA Locus Contains Novel Foetal Susceptibility Alleles for Congenital Heart Block with Significant Paternal Influence

Autor: Fredrik Gadler, Anders Hamsten, Anders Mälarstig, Anders Jonzon, Tomas Olsson, Bo Ding, Sven-Erik Sonesson, Sabrina Gorgen, Marie Wahren-Herlenius, Ingrid Kockum, Lars Alfredsson, Therese Östberg, Stina Salomonsson, Tomas Axelsson, Håkan Eliasson, Lars Klareskog
Rok vydání: 2013
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 72:A56.1-A56
ISSN: 1468-2060
0003-4967
DOI: 10.1136/annrheumdis-2013-203221.23
Popis: Objective To identify foetal susceptibility genes in Ro/SSA autoantibody-mediated congenital heart block on chromosome six. Methods Single nucleotide polymorphism (SNP) genotyping of individuals included in the Swedish Congenital Heart Block (CHB) study population was performed. Low resolution HLA-A, -Cw and -DRB1 allele typing was carried out in 86 families of the study population comprising 339 individuals (86 Ro/SSA autoantibody positive mothers, 71 fathers, 87 CHB index cases and 95 unaffected siblings). Results A case-control comparison between index cases and population-based out of study controls (n = 1710) revealed an association of CHB with fifteen SNPs in the 6p21.3 MHC locus at a chromosome-wide significance of p –6 (OR 2.21–3.12). In a family-based analysis between SNP markers as well as distinct MHC class I and II alleles with CHB we observed associations to HLA-DRB1*04 and HLA-Cw*05 variants that were significantly more often transmitted to affected individuals (p Conclusions Our study identifies HLA-DRB1*04 and HLA-Cw*05 as novel foetal HLA-allele variants that confer susceptibility to develop CHB in response to exposure to Ro/SSA autoantibodies, while DRB1*13 and Cw*06 emerged as protective alleles. For the first time, we also demonstrate paternal contribution to foetal susceptibility to CHB.
Databáze: OpenAIRE
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