Concomitant cathodic cleavage of carbamates and carbon-bromine bonds as key steps in the enzyme inhibitors synthesis

Autor:	Anne-Marie Martre, E. Rodrigues-Pereira, Michelle Prudhomme, Guy Mousset
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Bromine Bicyclic molecule General Chemical Engineering chemistry.chemical_element Electrochemistry Combinatorial chemistry Cathodic protection Enzyme chemistry Hydrogenolysis Organic chemistry Cyclic voltammetry Protecting group
Zdroj:	Electrochimica Acta. 40:1805-1809
ISSN:	0013-4686
DOI:	10.1016/0013-4686(95)00129-3
Popis:	The synthesis of the 4-(3-indolyl)-oxazol-2-one, a potential protein kinase C inhibitor, was performed by using electrochemistry as key step. The anodic methoxylation of an oxazolidin-2-one was achieved by this way in good yield. The high selectivity of the electrochemical method allowed then the aromatic carbon-bromine bond hydrogenolysis and the cleavage of N-oxazolone protecting group in a one-pot process simply by adjusting the appropriate cathodic potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ab0ae67909e3b4d1e5a637b48c51137 https://doi.org/10.1016/0013-4686(95)00129-3 Zobrazit plný text záznamu Full Text from ScienceDirect