Cd8+ Lymphocyte Activation At Human Immunodeficiency Virus Type 1 Seroconversion: Development Of Hla-Dr+ Cd38- Cd8+ Cells Is Associated With Subsequent Stable Cd4+ Cell Levels
| Autor: | Lance E. Hultin, Lawrence P. Park, Janis V. Giorgi, Hong Nerng Ho, Sheryl O'Rourke, John P. Phair, Joseph B. Margolick, Karim F. Hirji, Chen-Cheng Chou, John Ferbas |
|---|---|
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Journal of Infectious Diseases. 170:775-781 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, > 800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38- CD8+ cells was a marker of subsequent stable HIV disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|