Magnesium sulfate, chorioamnionitis, and neurodevelopment after preterm birth
| Autor: | Gregory J. Stoddard, M.W. Varner, Tracy A. Manuck, Manijeh Kamyar, Erin A.S. Clark |
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| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pregnancy education.field_of_study 030219 obstetrics & reproductive medicine Intention-to-treat analysis Obstetrics business.industry Population Obstetrics and Gynecology Subgroup analysis Chorioamnionitis medicine.disease 03 medical and health sciences 0302 clinical medicine Premature birth Relative risk medicine Gestation 030212 general & internal medicine education business |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 123:1161-1166 |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | Objective To assess the neuroprotective effect of magnesium sulfate (MgSO4) in preterm children exposed to chorioamnionitis. Design A secondary analysis of a multicentre randomised controlled trial of antenatal MgSO4 administered to women at risk of preterm birth for the prevention of cerebral palsy (CP). Singleton, non-anomalous pregnancies with clinical chorioamnionitis, delivering at ≥24 weeks of gestation, were selected. Cases were exposed to antepartum MgSO4; controls received placebo. Setting Multicentre randomised controlled trial. Population Singleton, non-anomalous pregnancies with clinical chorioamnionitis, delivering at ≥24 weeks of gestation. Methods All data were analysed by intention to treat. Univariate and multivariate analyses were performed. Main outcome measures Primary outcome was a composite of stillbirth, death by the age of 1 year, or moderate or severe CP by the age of 2 years. Secondary outcomes included a composite neonatal outcome as well as neurodevelopmental delay, defined as Bayley II mental and psychomotor developmental indices |
| Databáze: | OpenAIRE |
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