ULK1 polymorphisms confer susceptibility to pulmonary tuberculosis in a Chinese population
| Autor: | Chen Ww, Wan Bs, Zhang Rr, Wen C, Jin Chen, Liulin Luo, Liang L, Jun Yue, Yanlin Zhao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Tuberculosis integumentary system biology business.industry Haplotype Case-control study Single-nucleotide polymorphism macromolecular substances medicine.disease biology.organism_classification Mycobacterium tuberculosis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases Polymorphism (computer science) 030220 oncology & carcinogenesis Immunology Genotype medicine Allele business |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 23:265-271 |
| ISSN: | 1027-3719 |
| DOI: | 10.5588/ijtld.18.0174 |
| Popis: | Objective The autophagy pathway is a critical process in Mycobacterium tuberculosis infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in ULK1 and risk of tuberculosis (TB) in a Chinese Han population. Design We recruited 380 pulmonary tuberculosis (PTB) cases, 242 extra-pulmonary tuberculosis (EPTB) cases and 606 healthy controls from a Chinese Han population and sequenced ULK1. Five SNPs in ULK1 were selected to investigate the correlations between ULK1 polymorphisms and TB susceptibility. Results The rs7138581 C allele was associated with a reduced risk of PTB (P = 0.001), whereas the rs9481 A allele was associated with an increased risk (P = 0.025). The rs7138581 CG genotype was significantly associated with a low risk of PTB, with a higher PTB disease severity in clinical parameters. Estimation of haplotype frequencies in ULK1 revealed a protective haplotype CCGAA (P = 0.007) and a potential risk haplotype TGAAA (P = 0.010) for PTB. Conclusion These results demonstrated that ULK1 polymorphisms have significant associations with susceptibility to PTB. |
| Databáze: | OpenAIRE |
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