Formation of Phosphorylated 3H-Pyrroles fromNefIsocyanidePerkowAdducts and Tosylmethyl Isocyanide

Autor:	Ehsan Ghanbari, Reza Hosseinpour, Issa Yavari
Rok vydání:	2014
Předmět:	Sulfonyl chemistry.chemical_classification Organic Chemistry Perkow reaction Biochemistry Medicinal chemistry Catalysis Adduct Inorganic Chemistry chemistry Drug Discovery Organic chemistry Tosylmethyl isocyanide Physical and Theoretical Chemistry
Zdroj:	Helvetica Chimica Acta. 97:1004-1008
ISSN:	0018-019X
DOI:	10.1002/hlca.201300400
Popis:	Imidoyl chlorides, generated from isocyanides and acyl chlorides, react with trialkyl phosphites, in a Perkow-type reaction, to afford 3-(alkylimino)-2-[(dialkyloxyphosphoryl)oxy]acrylates, which undergo a smooth reaction with tosylmethyl isocyanide (TsMIC) to furnish 4-(alkylamino)-3-[(dialkyloxyphosphoryl)oxy]-5-[(4-methylphenyl)sulfonyl]-3H-pyrrole-3-carboxylates in moderate-to-good yields.
Databáze:	OpenAIRE
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