Colchicine-Induced Rhabdomyolysis and Possible Amiodarone Interaction ——Colchicine-Induced Rhabdomyolysis

Autor:	J. Sakhri, Houssem Hmouda, Besma Trimech, Bouraoui Kamel, Neila Fathallah, Chaker Ben Salem
Rok vydání:	2010
Předmět:	Acenocoumarol business.industry Pharmacology Drug interaction medicine.disease Amiodarone chemistry.chemical_compound Pericarditis chemistry Anesthesia Toxicity medicine Colchicine medicine.symptom Myopathy business Rhabdomyolysis medicine.drug
Zdroj:	Pharmacology & Pharmacy. :39-41
ISSN:	2157-9431 2157-9423
DOI:	10.4236/pp.2010.12006
Popis:	Objective: To report a case of drug interaction leading to rhabdomyolysis. Case Summary: A 65-year old woman suf-fering from chronic atrial fibrillation was treated with amiodarone and acenocoumarol. Two weeks after administration of conventional dosage of colchicine for pericarditis, the patient developed rhabdomyolysis. colchicine-induced rhabdomyolysis was suspected. Colchicine was stopped and the patient underwent supportive therapy. Clinical symptoms improved rapidly. Discussion: Colchicine-induced neuromuscular toxicity and rhabdomyolysis have been reported with chronic treatment in therapeutic doses. Concomitant use of several drugs with colchicine may potentiate the development of myopathy. In our case, a co-administration of colchicine, a well known substrate of cytochrome P450 3A4 and P-glycoprotein, and amiodarone had possibly precipitated rhabdomyolysis. Amiodarone may increase colchicine toxicity by a dual mechanism. Amiodarone inhibits P-glycoprotein which may theoretically result in increased intrace- llular colchicine concentrations and decreased hepatic and renal excretion of the drug. Conclusion: Amiodarone may potentiate the development of colchicine-induced rhabdomyolysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a951d1e91b74c3b6cef39094d823bc8 https://doi.org/10.4236/pp.2010.12006 Zobrazit plný text záznamu