Angiotensin II receptor blocker improves cardiac response to exercise in patients with non-ischemic heart failure

Autor: Shimada Yoshifumi, Mizuno Kiyoo, Osato Kazuo, Misawa Katsushi, Kokado Hiromasa, Saga Makoto, Junji Sakata, Moriuchi Ikuo, Murakami Tatsuaki
Rok vydání: 2004
Předmět:
Zdroj: Journal of Cardiac Failure. 10:S186
ISSN: 1071-9164
DOI: 10.1016/j.cardfail.2004.08.157
Popis: Background: Large scale clinical study is showing the importance of Angiotensin II Receptor Blocker(ARB). We investigated that ARB may improve subjective symptom, cardiac function, cardiac response to exercise in patients with non-ischemic heart failure. Object: The 20 patients with non-ischemic heart failure in a mild case could have cardiopulmonary exercise test(CPX) after giving common treatment of heart failure. Method: Patients receiving ARB alone or with diuretics had a measurement of brain natriuretic peptide(BNP), chest X-rayed, ultrasonic cardiograph and CPX at pre-treated, after 3 months and 6 months. The group received beta-blockers had the same protocol. Result: New York Heart Association functional class and left ventricular ejection fraction improved, BNP and cardiothoracic ratio decreased remarkably. Metabolic equivalent(METs), delta double products and %anaerobic threshold(%AT) also improved significantly. The group received beta-blockers had a result similar to ARB. Conclusion: ARB improved subjective symptom, cardiac function, cardiac response to exercise as beta-blockers did so. These findings suggest that ARB may have therapeutic benefits in patients with non-ischemic heart failure in a mild case.
Databáze: OpenAIRE
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