Application of the cross-organ beta dose method for tissue dosimetry in tumor-bearing mice treated with a90y-labeled immunoconjugate
| Autor: | Barbara G. Beatty, Darrell R. Fisher, Lawrence E. Williams, J. D. Beatty, T E Hui, J. A. Kuhn |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Biodistribution Pathology medicine.medical_specialty biology medicine.drug_class business.industry medicine.medical_treatment Monoclonal antibody Immunoconjugate Carcinoembryonic antigen Oncology Immunotoxin Radioimmunotherapy medicine biology.protein Dosimetry Beta (finance) business |
| Zdroj: | Cancer. 73:958-965 |
| ISSN: | 1097-0142 0008-543X |
| Popis: | Background. Radioimmunotherapy of nude mice bearing human tumor xenografts using 90 Y-labeled monoclonal antibodies has resulted in slower tumor growth, decreased tumor burden, and increased survival times. Dosimetry estimates in the murine model usually were based on biodistribution data and standard Medical Internal Radiation Dose approaches. A new dosimetric model for the mouse that takes into consideration the small dimensions, mass, and proximity of murine organs has been developed based on self-organ absorbed and cross-organ doses. Methods. Nude mice bearing carcinoembryonic antigen-expressing WiDr human colon cancer xenografts were injected with 240 μCi 90 Y-anti-carcinoembryonic-antigen monoclonal antibodies and then killed at 12, 24, 72, 120, and 168 hours |
| Databáze: | OpenAIRE |
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