| Autor: |
Jessica Becker, Ines Gockel, Markus M. Nöthen, Hauke Lang, Mira M. Wouters, Michael Knapp, Henning G. Schulz, Johannes Schumacher, Michaela Müller, Stefan Niebisch, Guy E. Boeckxstaens |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Gastroenterology. 146:S-146 |
| ISSN: |
0016-5085 |
| DOI: |
10.1016/s0016-5085(14)60518-7 |
| Popis: |
G A A b st ra ct s but significantly decreased mean liver weight and the mean liver-to-body weight ratio compared to the vehicle group. Furthermore, treatment with SOLI improved glucose metabolism as evidenced by reduction of whole blood glucose levels. These changes were accompanied with a significant improvement in the histological score of NASH (NAFLD Activity Score [NAS]). There was no difference in triglycerides between the SOLI treated and vehicle treated mice. MCP-1 and MMP9 mRNA expression levels were significantly decreased in the liver. CONCLUSION: SOLI has demonstrated potential anti-NASH and anti-hyperglycemic effects in the present study. Because NAS is a clinical endpoint used to assess the treatment of NASH, these observed changes in the treatment group suggest potential for SOLI in the treatment of NASH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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