Androgenstoffwechsel und Leydig-Zellfunktion bei akuten und chronischen Lebererkrankungen*
| Autor: | H. Gerdes, K.-P. Littmann, G.A. Martini |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Androsterone Leydig cell business.industry Urinary system Stimulation General Medicine medicine.disease Chronic liver disease chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Medicine business Testosterone glucuronide Testosterone |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 100:1881-1887 |
| ISSN: | 1439-4413 0012-0472 |
| Popis: | Diurnal variations of plasma testosterone and urinary excretion rates of testosterone-, androsterone-, aetiocholanolone-, and DHA-glucuronide, as well as DHA-sulphate were measured before and after selective Leydig-cell stimulation (with 3 X 5000 IU human gonadotrophin) in eight patients with alcoholic liver cirrhosis, ten with acute hepatitis and four with haemochromatosis. The circadian variation of plasma testosterone and the maximal testosterone concentration after human gonadotrophin stimulation were decreased in patients with cirrhosis and haemochromatosis, while in those with acute hepatitis the diurnal variations were evened out, whereas individual values were within the normal range. Urinary excretion of free testosterone and testosterone glucuronide was significantly reduced in those with cirrhosis and haemochromatosis before and after stimulation. The urinary pattern of C19 steroid metabolites was markedly changed in favour of the 5 alpha-steroids in acute heaptitis, cirrhosis, and haemochromatosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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