Assessment of Autofluorescence to Detect the Remineralization Capabilities of Sodium Fluoride, Monofluorophosphate and Non-Fluoride Dentifrices
| Autor: | W. Yin, R.P. Ellwood, Y.P. Zhang, I.A. Pretty, Y. Feng, Deyu Hu |
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| Rok vydání: | 2007 |
| Předmět: |
Remineralisation
Enamel paint Radiochemistry Inorganic chemistry Sodium monofluorophosphate Monofluorophosphate stomatognathic diseases chemistry.chemical_compound Autofluorescence stomatognathic system chemistry visual_art Sodium fluoride Dentifrice visual_art.visual_art_medium General Dentistry Fluoride |
| Zdroj: | Caries Research. 41:358-364 |
| ISSN: | 1421-976X 0008-6568 |
| DOI: | 10.1159/000104793 |
| Popis: | The purpose of the study was to determine if longitudinal measurements of enamel autofluorescence (quantitative light-induced fluorescence, QLF) could detect differences in remineralization of early enamel caries on buccal surfaces of anterior teeth following supervised daily brushing with either sodium fluoride (NaF; 1,450 ppm F), sodium monofluorophosphate (MFP; 1,450 ppm F) dentifrices or a herbal, non-fluoride placebo dentifrice. The study was a pragmatic cluster-randomized controlled trial with schools as the unit of randomization. Twenty-one schools in Chengdu, China, comprised the clusters; 296 children with at least 1 visible white-spot lesion were examined using QLF at baseline and after 3 and 6 months. Each of the 21 clusters was randomly assigned 1 of the 3 dentifrices, and the childrenbrushed under supervision once per day for 2 min. The primary outcome measure was ΔQ (product of fluorescence loss and area) at a 5% threshold after 6 months of product use. A multi-level model was fitted to the data at the site level, taking into account the hierarchical structure with baseline ΔQ, age and sex as covariates. After 3 months there was a significant difference between the MFP group and placebo (p = 0.02) and after 6 months between the NaF group (p = 0.002), MFP group (p < 0.001) and the placebo. QLF methodology could detect, within 3- and 6-month periods of supervised brushing, a difference in remineralization between fluoride-containing and non-fluoride-containing dentifrices. Typically lesions in all 3 treatment groups demonstrated improvement. Groups receiving fluoride experienced a more rapid and more substantial remineralization than those in the placebo group. |
| Databáze: | OpenAIRE |
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