Atypical toxoplasmic retinochoroiditis in patients with malignant hematological diseases
| Autor: | Aina Moll-Udina, J.P. Figueroa-Vercellino, L. Miguel, Carmen Alba-Linero, Victor Llorenç, Alfredo Adán |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry medicine.medical_treatment Immunosuppression General Medicine Disease 030108 mycology & parasitology medicine.disease Dermatology Toxoplasmosis law.invention Serology 03 medical and health sciences 0302 clinical medicine law 030221 ophthalmology & optometry medicine In patient business Uveitis Polymerase chain reaction Atovaquone medicine.drug |
| Zdroj: | Archivos de la Sociedad Española de Oftalmología (English Edition). 96:152-156 |
| ISSN: | 2173-5794 |
| Popis: | In immunocompromised patients, toxoplasmosis may have atypical presentation with bilateral, extensive or multifocal involvement. We report a case series of atypical toxoplasmic retinocoroiditis in patients with malignant hematological diseases who are usually immunosuppressed. Four patients were diagnosed of atypical toxoplasmic retinochoroiditis, all of them had immunosuppression (100%) and half of them (50%) had received a bone marrow transplant. The polymerase chain reaction for toxoplasma was positive in 75% of cases, and in one case (25%) the diagnosis was made with clinical and serological criteria. One patient presented ocular toxoplasmosis despite being on prophylactic treatment with atovaquone. Patients with atypical ocular toxoplasmosis and hematological diseases are generally immunocompromised, but they do not always have history of a bone marrow transplant. The presentation may be due to a primary infection or a reactivation of the disease. The aqueous humor and/or vitreous polymerase chain reaction allow confirming the diagnosis to perform a proper treatment. |
| Databáze: | OpenAIRE |
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