Direct nucleophilic substitution of polyfluorobenzenes with pyrrole and 2,5-dimethylpyrrole
| Autor: | Katarína Hrnčariková, Zita Tokárová, Daniel Végh, Pavol Tisovský, Róbert Balogh |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Substitution (logic) Hexafluorobenzene chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Nucleophile Fluorine Nucleophilic substitution Environmental Chemistry Organic chemistry Physical and Theoretical Chemistry Pyrrole |
| Zdroj: | Journal of Fluorine Chemistry. 204:59-64 |
| ISSN: | 0022-1139 |
| Popis: | A series of novel N -pyrrolyl-, N -(2,5-dimethyl)pyrrolyl- and N -(2,5-dithiophen-2-yl)pyrrolyl- partially fluorinated and/or fully substituted benzenes have been prepared by the nucleophilic substitution of fluorine (S N Ar) in hexafluorobenzene, 1-pentafluorophenyl-1H-pyrrole; 2,5-dimethyl-1-pentafluorophenyl-1H-pyrrole; 2,5-di(thiophen-2-yl)pentafluorophenyl and 2,3,5,6-tetrafluoroterephtalonitrile. The observed substitution pattern indicates the gradual defluorination of particular fluorine atoms depending on the nature and amount of the used nucleophile (pyrrole/NaH vs. 2,5-dimethylpyrrole/NaH). |
| Databáze: | OpenAIRE |
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