A Numerical Prognostic Index for Clinical use in Identification of Poor-Risk Patients with Hodgkin's Disease at Diagnosis

Autor:	Penny Taylor, Stephen J. Proctor, Michael J. Mackie, Robin J Prescott, Anne Lennard, Peter Donnan, Richard J. Boys
Rok vydání:	1992
Předmět:	Cancer Research medicine.medical_specialty Index (economics) Multivariate analysis business.industry Separation (statistics) Univariate Hematology Disease medicine.disease Lymphoma Surgery Oncology Internal medicine medicine Stage (cooking) business Progressive disease
Zdroj:	Leukemia & Lymphoma. 7:17-20
ISSN:	1029-2403 1042-8194
DOI:	10.3109/10428199209061558
Popis:	The aim of this study was to assess the feasibility of using objective data obtained at the time of diagnosis of Hodgkin's disease to predict those patients who were likely to die of progressive disease within four years.Nintey-two consecutive patients from one centre (Newcastle upon Tyne) were used to construct a numerical index based on disease stage (Ann Arbor), age, haemoglobin and absolute lymphocyte count. Weight was assigned according to a predictive value from univariate and multivariate analyses based on survival. The index produced was then validated on a separate patient set (455) from other centres within the Scotland and Newcastle Lymphoma Group (SNLG) on whom the same prospective information was available. The index produced provided a useful separation of those patients destined to die of disease. In 101 patients with index >0.5, 62 (61.4%) were dead at four years, whereas with index
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a74f3d8adeef515188e8a1b8c700a51 https://doi.org/10.3109/10428199209061558 Zobrazit plný text záznamu