Biochemical Assessment and Clinical Evaluation of a Non-Ionic Adsorbent Resin in Patients with Intractable Jaundice
| Autor: | G. Lodi, S. Gullini, Puviani Ac, E. Morsiani, R. Scagliarini, Paolo Pazzi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Chromatography Bile acid Bilirubin medicine.drug_class 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Bioengineering General Medicine Absorption (skin) 030204 cardiovascular system & hematology Jaundice In vitro Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adsorption chemistry Activated charcoal In vivo medicine medicine.symptom |
| Zdroj: | The International Journal of Artificial Organs. 23:312-318 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139880002300505 |
| Popis: | We investigated in vitro and in vivo the ability of a non-ionic adsorbing resin (styrenedivinylbenzene copolymer) to remove bilirubin and bile acids from human plasma. In preliminary experiments, human plasma from healthy donors, enriched in conjugated bile acids and bilirubin, and pooled plasma from jaundiced patients were recirculated through the resin column. The removal of bilirubin and bile acids was evaluated at two different flow rates (200 ml/min and 40 ml/min), and compared to an activated charcoal column. Four patients with severe jaundice were subsequently treated by 4-hour plasmaperfusion through the resin. The in vitro studies showed that after 1 hour the removal of bile acids was almost complete and bilirubin level decreased significantly, reaching a plateau after 4 hours. In the in vivo study, all treatments were well tolerated. After plasmaperfusion, serum bile acid levels decreased by 64.9–94.6% and total bilirubin by 35.3–57.7%. No clinical or biochemical side effects were observed. Our data suggest that plasmaperfusion through this resin is safe and efficient for removal of bilirubin and bile acids in jaundiced patients. Thus, it may serve as a method of artificial liver support in the treatment of cholestatic syndromes. |
| Databáze: | OpenAIRE |
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