Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles Derivatives from the Resin-Bound Acylhydrazines

Autor:	Chao Mai, Xingang Liu, Rongjian Xie, Zhanxiang Liu
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Solid-phase synthesis chemistry Hydrochloride Yield (chemistry) Condensation Acylhydrazine Organic chemistry
Zdroj:	International Journal of Organic Chemistry. :35-40
ISSN:	2161-4695 2161-4687
Popis:	An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles resin with the corresponding arylamines hydrochloride to form the the resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were obtained from resin-bound acylhydrazines in several steps providing 78% - 87% overall yields and excellent purity. The advantages of this method include straightforward operation and high yield and purity of the products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a64b247cd7c519b884a572e5338fa80 https://doi.org/10.4236/ijoc.2013.31a004 Zobrazit plný text záznamu