Highly Enantioselective Synthesis of Chiral γ-Lactams by Rh-Catalyzed Asymmetric Hydrogenation
| Autor: | Qin Yin, Guoxian Gu, Yaoti Cheng, Qiwei Lang, Xumu Zhang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry Asymmetric hydrogenation Enantioselective synthesis Substituent General Chemistry biochemical phenomena metabolism and nutrition 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Yield (chemistry) polycyclic compounds Enantiomeric excess |
| Zdroj: | ACS Catalysis. 8:4824-4828 |
| ISSN: | 2155-5435 |
| DOI: | 10.1021/acscatal.8b00827 |
| Popis: | A Rh/bisphosphine-thiourea (ZhaoPhos) catalytic system has been identified for the straightforward asymmetric synthesis of chiral γ-lactams. A variety of NH free α,β-unsaturated lactams bearing a β-aryl or β-alkyl substituent were smoothly hydrogenated to provide the desired γ-lactams in up to 99% yield and 99% enantiomeric excess (ee). This methodology provides a highly practical pathway to synthesize chiral γ-lactams or γ-amino acids. |
| Databáze: | OpenAIRE |
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