Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination

Autor:	Junghyun Baek, Hakjune Rhee, Saira Shabbir, Jaeyoung Ban, Minkyung Lim
Rok vydání:	2019
Předmět:	010405 organic chemistry Carbazole Aryl Organic Chemistry Substrate (chemistry) chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry Copper Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Intramolecular force N acetylation Amination
Zdroj:	Synthesis. 52:917-927
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0039-1690759
Popis:	We synthesized various carbazoles from anilines through a three-step process with good overall yields (up to 48%). This process comprises N-acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramolecular amination. It permits various functional­ groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a5b185255b3c56f224e44aceea99404 https://doi.org/10.1055/s-0039-1690759 Zobrazit plný text záznamu