Anti-Allergic Effects of Peppermint Oil, Chicle and Jelutong

Autor:	Masaki Shibata, Koh Kawasumi, Tokinori Watanabe, Yoshiharu Honma, Tsutomu Arakawa, Kazuo Hosomi, Yoshio Takeuchi
Rok vydání:	1992
Předmět:	biology Dyera costulata General Medicine Smooth muscle contraction Pharmacology biology.organism_classification Immunoglobulin E Chewing gum Menthone Chicle chemistry.chemical_compound chemistry biology.protein Anti allergy Organic chemistry Histamine
Zdroj:	Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi). 33:569-575_1
ISSN:	1882-1006 0015-6426
DOI:	10.3358/shokueishi.33.569
Popis:	Anti-allergic effects of constituents of chewing gum were investigated in Type I allergic reactions. The results were as follows.Oral administration of 1, 8-cineole and n-BuOH extract of jelutong (J-4), a natural resin of Dyera costulata Hook. f., inhibited homologous passive cutaneous anaphylaxis (PCA) mediated by IgE antibody in guinea pigs. Peppermint oil, l-menthol, 1, 8-cineole, J-4 and n-BuOH extract of chicle (C-4) from Achras zapota L suppressed PCA when intraperitoneally injected. Further investigation on the above constituents showed that l-menthol, menthone, 1, 8-cineole and C-4 suppressed antigen-induced histamine release from rat peritoneal mast cells. In the Schultz-Dale reaction, some of them suppressed smooth muscle contraction induced by either histamine or serotonin.From these results, it is concluded that these constituents of chewing gum have antiallergic effects.
Databáze:	OpenAIRE
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