Analysis of Phosphatidylcholines Alterations in Human Glioblastomas Ex Vivo

Autor:	S. I. Pekov, Alexander Potapov, D. S. Bormotov, Artur A. Kuzin, Eugene N. Nikolaev, Anatoly Sorokin, Igor Popov, A. S. Shivalin, V A Shurkhay, K. V. Bocharov
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Chemistry Lipid composition Clinical Biochemistry Astrocytoma medicine.disease Biochemistry Mass spectrometric De novo synthesis medicine Molecular Medicine Who classification Ex vivo Oxygen starvation Polyunsaturated fatty acid
Zdroj:	Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 15:241-247
ISSN:	1990-7516 1990-7508
Popis:	The analysis of data obtained using ambient mass spectrometric profiling of clinical samples of primary and secondary human glioblastomas ex vivo, revealed changes in the lipid composition of tissues accompanying the development of grade IV glial tumors (according to the WHO classification). It has been shown that both primary and secondary (developed from astrocytoma) tumors are enriched with mono- and di-unsaturated phosphatidylcholines (PC 26:1, 30:2, 32:1, 32:2, 34:1, 34:2). At the same time, the content of saturated and polyunsaturated phosphatidylcholines and phosphatidylethanolamines decreases. These changes are associated both with altered availability of polyunsaturated fatty acids and activation of de novo synthesis and beta-oxidation of fatty acids under conditions of oxygen starvation in the tumor body.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a4c101557a3608c6a838816b28f5a30 https://doi.org/10.1134/s1990750821030070 Zobrazit plný text záznamu Full text from SpringerLink