Concentration and protein binding of cephalosporins in renal interstitial fluid, soft-tissue interstitial fluid, urine and serum
| Autor: | H. U. Eickenberg |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.drug_class Chemistry Cephalosporin Antibiotics Urology Cefazolin Soft tissue General Medicine Urine urologic and male genital diseases Infectious Diseases Endocrinology Pharmacokinetics Interstitial fluid Internal medicine medicine Cefamandole medicine.drug |
| Zdroj: | Infection. 6:S233-S237 |
| ISSN: | 1439-0973 0300-8126 |
| DOI: | 10.1007/bf01638980 |
| Popis: | Utilizing multiperforated capsules implanted in tissue, the concentrations of cephalothin, cefazolin and cefamandole in soft tissue interstitial fluid and renal interstitial fluid were measured simultaneously and compared with concentrations found in serum and urine in dogs. Antibiotic concentration in renal interstitial fluid was less than urinary levels but exceeded serum concentrations. A direct time-concentration relationship of these three structurally related antibiotics with different protein-binding in serum and renal interstitial fluid was found. This model helps illuminate the basic pharmacokinetics of antibiotic in the renal interstitium where pyelonephritis occurs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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