N-Benzyl-Protection of Amino Acid Derivatives by Reductive Alkylation with α-Picoline-Borane

Autor:	Tadashi Kataoka, Tsutomu Yokomatsu, Kimio Ueda, Teruo Kutsuma, Takeo Iwakuma, Takehiro Yamagishi, Yasushi Kawase, Tadashi Nakata
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Aryl Organic Chemistry Benzyl group Picoline Methanol Borane Alkylation Medicinal chemistry Catalysis Amino acid
Zdroj:	Synthesis. 2010:1673-1677
ISSN:	1437-210X 0039-7881
Popis:	A convenient method for N-protection of amino acid derivatives with a benzyl group by reductive alkylation of amino acid derivatives with α-picoline-borane is described. Amino acid esters or amino alcohols were treated with aryl aldehydes in methanol/acetic­ acid in the presence of α-picoline-borane to give N-benzyl-protected amino acid derivatives in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a3d2a09d10bb4c43e2a6b4b1d0345c0 https://doi.org/10.1055/s-0029-1218707 Zobrazit plný text záznamu