Role of lung biopsy in patients undergoing a modified Fontan procedure
| Autor: | Robert L. Geggel, Lynne Reid, Ruthellen Fried, John E. Mayer, Cook Ef, Hrodmar Helgason |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Autopsy Lung biopsy Perioperative medicine.disease Surgery Fontan procedure medicine.artery Pulmonary artery Biopsy Medicine Tricuspid atresia Risk factor Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 99:451-459 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(19)36975-2 |
| Popis: | Fifty-six patients undergoing a modified Fontan procedure from 1977 to 1985 had lung tissue available from the perioperative period (n = 51) or recent palliative procedure (n = 5) (37 biopsy, 12 autopsy, 7 biopsy and autopsy). Twenty-six patients had tricuspid atresia, and 30 had other causes of functional univentricular heart. Pulmonary arterial structure was classified by both the Heath-Edwards and morphometric scales. Biopsy and autopsy grades were identical except for a minor difference in Heath-Edwards scale in one case. Elevated preoperative mean pulmonary artery pressure (>15 mm Hg) was associated with medial hypertrophy (p = 0.04), although six patients with normal pulmonary artery pressure had medial hypertrophy and six patients with mean pulmonary artery pressure greater than 15 mm Hg did not have medial hypertrophy. Medial hypertrophy was a possible risk factor in patients with univentricular heart: Patients with medial hypertrophy had a ninefold greater risk of death (p = 0.08). Controlling for confounding variables did not alter this result (0.06 |
| Databáze: | OpenAIRE |
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