Study of electrokinetic potential of drug micro-carriers prepared from resorbable polymers bioplastotan

Autor:	Tatiana G. Volova, Anna M. Shershneva, Ekaterina I. Shishatskaya, A. V. Murueva
Rok vydání:	2014
Předmět:	Drug Materials science media_common.quotation_subject Phosphate buffered saline Biophysics Electrokinetic phenomena Chemical engineering Solvent evaporation Spray drying Emulsion Organic chemistry Physical stability Resorbable polymers media_common
Zdroj:	Biophysics. 59:561-567
ISSN:	1555-6654 0006-3509
Popis:	The study investigates electrokinetic potentials of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ζ-potential of microparticles prepared from emulsion by solvent evaporation method was −20 mV; the ζ-potential of microparticles prepared by spray drying was reduced to −95 mV. The value of ζ-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a22ab41c3a1398a0376af63120a03df https://doi.org/10.1134/s000635091404023x Zobrazit plný text záznamu Full text from SpringerLink