| Autor: |
Mailliez A, Charles Coutant, Marc Espié, Berkach C, Maitrot L, Fabien Reyal, Giacchetti S, Decanter C, Lucie Laot, Julien Guerin, C Sautter, Aullene Toussaint, Sablone L, Julie Labrosse, Rousset C, Enora Laas, Plu-Bureau G, P Santulli, Fumoleau P, Clara Sebbag, Ines Abdennebi, Anne-Sophie Hamy, Jacot W, Elise Dumas, Nadir Sella, Khallouch S, Bernard Asselain, Bobrie A, Manon Mangiardi-Veltin, Wang Y, Ray-Coquard I, Chapron C, Senechal-Davin C, Delrieu L, Manuel Rodrigues, Florence Coussy |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
ObjectiveTo study fertility concerns and oncofertility practices at time of breast cancer (BC) diagnosis.DesignThe FEERIC study (Fertility, Pregnancy, Contraception after BC in France) is a prospective, multicenter study.SettingWeb-based collaborative research platform Seintinelles.Patients517 patients with prior BC diagnosis free from relapse and aged 18 to 43 years at inclusion (from 12th March 2018 to 27th June 2019).InterventionBaseline online self-administered questionnaires.Main Outcome MeasureFertility preservation procedures at BC diagnosis.ResultsMedian age at BC diagnosis was 33.6 years and 424 patients (82.0%) received chemotherapy. Overall, 236 (45.6%) patients were offered specialized oncofertility counseling, 124 (24.0%) underwent one or more FP procedures with material preservation (oocytes n=108, 20.9%; embryos n=31, 6.0%; both oocytes and embryos n=13, 2.5%; ovarian cryopreservation n=6, 1.2%) and 78 patients received gonadotropin-releasing hormone agonists (15.1%). With a median follow-up of 26.7 months after the end of treatments,133 pregnancies (25.7%) had occurred in 85 patients (16.4%), including 20 unplanned pregnancies (15.0%). Most of the pregnancies were spontaneous (n=113, 87.6%), while 16 (12.4%) required medical interventions. Patients who had an unplanned pregnancy were less likely to have received fertility counseling (p=0.02) and contraceptive counseling (p=0.08) at BC diagnosis.ConclusionMost of the patients were not offered proper specialized oncofertility counseling at the time of BC diagnosis. Spontaneous pregnancies after BC were very much more frequent than pregnancies resulting from the use of cryopreserved gametes. Adequate contraceptive counseling seems as important as information about fertility and might prevent unplanned pregnancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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