| Popis: |
Oxidative and nitrosative stress have been implicated in the pathogenesis and progression of human immune deficiency virus (HIV) infection, and seem to be more pronounced with commencement of highly active antiretroviral therapy (HAART). Evaluation of markers of oxidative and nitrosative stress may be useful indices for monitoring progress of infection and development of adverse drug reactions. The total antioxidant capacity (TAC), total plasma peroxides (TPP), oxidative stress index (OSI), nitric oxide (NO), reduced form of glutathione (GSH), malondialdehyde (MDA), and catalase activity were estimated in HIV-infected individuals with or without HAART. A total of 90 consenting subjects comprising of 30 HIV seropositive subjects on HAART, 30 HAART naive and 30 apparently healthy HIV seronegative controls resident in Calabar were recruited into the study. TAC, TPP, NO, GSH, MDA, and catalase activity were determined using colorimetric methods, CD4+ T cell count was done by flow cytometry while body mass index (BMI) and oxidative stress index were determined by calculation. Data was analyzed using ANOVA, LSD post hoc and Pearson’s correlation at p |
