Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients
| Autor: | César Ávila, Alfonso Barrós-Loscertales, Noelia Ventura-Campos, Juan-José Llopis, Víctor Costumero, Patricia Rosell-Negre, Paola Fuentes-Claramonte, Juan-Carlos Bustamante |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
medicine.medical_specialty medicine.diagnostic_test Addiction media_common.quotation_subject Ventral striatum Medicine (miscellaneous) Striatum Nucleus accumbens Abstinence Audiology Anticipation Psychiatry and Mental health Reward system medicine.anatomical_structure medicine Psychiatry Psychology Functional magnetic resonance imaging media_common |
| Zdroj: | Addiction Biology. 19:885-894 |
| ISSN: | 1355-6215 |
| DOI: | 10.1111/adb.12041 |
| Popis: | Pre-clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with monetary reinforcement, we studied striatal functional alterations in long-term abstinent cocaine-dependent patients and striatal functioning as a function of abstinence and treatment duration. Eighteen patients and 20 controls underwent functional magnetic resonance imaging during a Monetary Incentive Delay task. Region of interest analyses based on masks of the dorsal and ventral striatum were conducted to test between-group differences and the functional effects in the cocaine group of time (in months) with no more than two lapses from the first time patients visited the clinical service to seek treatment at the scanning time (duration of treatment), and the functional effects of the number of months with no lapses or relapses at the scanning session time (length of abstinence). We applied a voxel-wise and a cluster-wise FWE-corrected level (pFWE) at a threshold of P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|