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Background Moderate exercise improves the functions of the immune system. The results of serum immunoglobulins in response to acute physical exercise are conflicting, but in general, there is an increase in serum immunoglobulins in athletes and non-athletes after maximal and submaximal exercise. The effects of acute physical exercise on serum immunoglobulin in patients with systemic lupus erythematosus are unknown. Objectives To determine the serum levels of IgG, IgM and IgA immunoglobulins in patients with systemic lupus erythematosus after a single session of acute aerobic exercise. Methods Thirty-one women with SLE (ACR1997 and/or SLICC 2012 criteria),11 with active lupus and 20 with inactive lupus, and 24 healthy women, who were matched by gender, age, and body mass index, participated in this study. All subjects underwent a maximal exercise test on motorized treadmill, with increases in velocity every minute until exhaustion, to evaluate the speed (km/h), heart rate, Borg scale (6-20), and the reason for stopping the test (fatigue and/or dyspnea). Samples of blood were collected in the morning, after an 8-hour fast and immediately after acute physical activity, and stored in a freezer at -80°C until the tests were performed. Immunoglobulin IgG, IgM and IgA assay was performed by turbitometry according to the manufacturer (Turbiquest, Labtest Diagnostic S.A). Results There was an increase in both IgG and IgA serum levels after physical activity in SLE patients (p = 0.004 for IgG and p = 0.002 for IgA) and healthy controls (p Conclusion Patients with SLE, mainly with inactive disease, responded to acute physical exercise with increased IgG and IgA serum levels, similarly to healthy controls. References [1] Nehlsen-Cannarella SL, et al. The effects of acute moderate exercise on lymphocyte function and serum immunoglobulin levels. Int J Sports Med. 1991; 12(4): 391-398.. [2] Nieman DC and Nehlsen-Cannarella SL.The effects of acute and chronic exercise of immunoglobulins. Sports Med. 1991; 11(3): 183-201. [3] Ochoa-Martinez PY, et al. Cinetica de la inmunoglobulina-A salival (IgAs) en adultos jovenes con capacidad aerobica promedio o excelente antes y despues de una prueba de esfuerzo maximo. Revista Chilena de Infectologia, 2017; 34: 27-32. Disclosure of Interests None declared |
