Successful Treatment of Hyperbilirubinemia by Monitoring Serum Unbound Bilirubin in an Extremely Preterm Infant with Bacterial Infection
| Autor: | Izumi Kishi, Daichi Katayama, Ichiro Morioka, Takayuki Imaizumi, Ryoji Aoki, Nobuhiko Nagano, Kazunori Kayama, Ryota Kato, Midori Hijikata, Takuya Akimoto, Kazumasa Fuwa, Aya Okahashi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bilirubin business.industry medicine.drug_class Antibiotics Albumin Gastroenterology Extremely Preterm Infant General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Amikacin Ampicillin Internal medicine Medicine Vancomycin business medicine.drug |
| Zdroj: | Clinical Laboratory. 67 |
| ISSN: | 1433-6510 |
| Popis: | Background Bacterial infections and some antibiotics show displacer effects on bilirubin-albumin binding and increase unbound bilirubin (UB) but not total bilirubin (TB) in serum. Methods A case study was conducted to show a successful treatment of hyperbilirubinemia by monitoring UB. Results In an extremely preterm infant with bloodstream bacterial infection caused by methicillin-resistant coagulase-negative staphylococci, 2 days after high-dose ampicillin and regular-dose amikacin were initiated, UB markedly increased, but TB did not. After vancomycin was substituted, UB decreased immediately with phototherapy and intravenous albumin infusion. Conclusions When using antibiotics, the clinicians should be mindful regarding the displacer effect on bilirubin-albumin binding. |
| Databáze: | OpenAIRE |
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