| Autor: |
Fabrizio Manca, Maria Grazia Costa, A Giannetti, Giampiero Girolomoni, M. T. Valle, Valentina Zacchi |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781461358114 |
| DOI: |
10.1007/978-1-4615-1971-3_106 |
| Popis: |
Dendritic cells (DC) play a dominant role in T cell priming both in vitro and in vivo. We have shown that peripheral blood (PB) DC are the most efficient APC for presentation of the HIV-1 envelope glycoprotein gpl20 to specific CD4+ T cells and are required for in vitro generation of gp120-specific T cell lines from unprimed individuals1. Epidermal DC, i.e. Langerhans cells (LC), are the critical APC for the induction of T cell immunity against Ag that are present in or penetrate through squamous epithelia2. LC obtained from HIV-infected subjects contain HIV-1 proviral DNA and RNA3, and can release HIV virions, thus indicating that LC are productively infected by the virus in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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