Potencies of Ceftriaxone and Cefotaxime in a Single Chamber Pharmacokinetic System Simulating Their in vivo Half-Lives1

Autor:	I H Patel, J Sattler, Joel Unowsky
Rok vydání:	1989
Předmět:	Pharmacology Cefotaxime biology medicine.drug_class Cephalosporin Antibiotics General Medicine biology.organism_classification Enterobacteriaceae Microbiology Infectious Diseases Oncology Pharmacokinetics In vivo Drug Discovery medicine Ceftriaxone Potency Pharmacology (medical) medicine.drug
Zdroj:	Chemotherapy. 35:338-344
ISSN:	1421-9794 0009-3157
DOI:	10.1159/000238692
Popis:	Ceftriaxone and cefotaxime are third-generation cephalosporins with similar in vitro potencies and spectra. However, previous studies have shown that ceftriaxone had superior in vivo activity (mouse PD50 values greater than or equal to 2-fold lower) compared to cefotaxime in 23 of 46 tested enterobacteriaceae. This superior activity was thought to be due to ceftriaxone's 5- to 8-fold longer half-life. The relationship between half-life (ceftriax-one 6 h, cefotaxime 1 h) and potency was examined by following bacterial kill curves in a single chamber, open-ended perfusion model over an 8-hour period. Both antibiotics were compared for efficacy at both half-lives against four gram-negative bacteria. For two of the bacterial strains antibiotic potency differences in the perfusion model were determined largely by pharmacokinetics. For the other two strains intrinsic bacterial and antibiotic properties were of prime importance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a0136484dcd5903c4f1c8be776463d2 https://doi.org/10.1159/000238692 Zobrazit plný text záznamu