COMPARATIVE STUDIES OF THE EFFECTS OF ESTRADIOL AND STILBESTROL UPON THE BLOOD, LIVER, AND BONE MARROW1

Autor:	Elson B. Helwig, Cyril M. MacBRYDE, Olga Bierbaum, Dante Castrodale
Rok vydání:	1941
Předmět:	medicine.medical_specialty medicine.drug_class Nausea business.industry Diethylstilbestrol Jaundice Endocrinology Estrogen Edema Internal medicine medicine Stilbestrol Vomiting medicine.symptom Headaches business medicine.drug
Zdroj:	Endocrinology. 29:363-372
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-29-3-363
Popis:	THE SYNTHETIC ESTROGEN, 4,4-dihydroxy, αβ diethylstilbene (stilbestrol) has been subjected to intensive clinical investigation during the past 2 years. It has been demonstrated that this diphenolic estrogenic substance is capable of relieving the symptoms brought about by a deficiency of the ovarian hormone and that it has a high potency when it is compared with the available estrogens derived from natural sources. In some instances, however, the administration of stilbestrol has been accompanied by unpleasant symptoms, the most frequent of which is nausea, either with or without vomiting. The reported incidence of nausea as reported by different investigators has ranged from 7 to 80%. Among other less frequent disagreeable manifestations which have been reported are abdominal cramps, headaches, edema, rashes, jaundice, salivation, diarrhea and paresthesia. It has been suggested, but without conclusive evidence, that the liver may be damaged.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09fd5c0a4af114da1d4e6bf0af69b8d3 https://doi.org/10.1210/endo-29-3-363 Zobrazit plný text záznamu