Aromatic ethers of 1-aryl 2-(1H-azolyl)ethanol: study of antifungal activity

Autor:	J. P. Seguela, C Tournaire, R. Caujolle, M. D. Linas, Marc Payard, Y Wahbi
Rok vydání:	1995
Předmět:	Pharmacology chemistry.chemical_classification Aryl Organic Chemistry Substituent 1 2 4-Triazole Ether General Medicine Medicinal chemistry Chemical synthesis chemistry.chemical_compound chemistry Drug Discovery medicine Azole Imidazole Miconazole medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 30:955-962
ISSN:	0223-5234
Popis:	Summary Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida . We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::09fa6dee717e1ef9c17adcf6a2bf4de0 https://doi.org/10.1016/0223-5234(96)88315-2 Zobrazit plný text záznamu Full Text from ScienceDirect